Monograph of Flumazenil
Introduction Flumazenil is a selective antagonist of the benzodiazepine binding site on the gamma-aminobutyric acid type A (GABAA) receptor complex. The drug…
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Monograph of Dimercaprol
Introduction Definition and Overview Dimercaprol, also known as British anti‑arsenical (BAA) and by the trade name Panchel, is a chelating agent characterized…
Monograph of Penicillamine
Introduction Penicillamine, a sulfur-containing dithiol compound, has been employed in a variety of therapeutic contexts since its discovery in the 1950s. The…
Desferrioxamine Monograph
Introduction Desferrioxamine, also known as deferoxamine or Desferal®, is a hexadentate siderophore used primarily for the chelation of excess iron in patients…
Trastuzumab
Introduction/Overview Trastuzumab is a humanized monoclonal antibody directed against the extracellular domain of the human epidermal growth factor receptor 2 (HER2). It…
Rituximab
Introduction/Overview Rituximab is a chimeric monoclonal antibody directed against the CD20 antigen expressed on B‑lymphocytes. It has become a cornerstone in the…
Monograph of Bleomycin
Introduction/Overview Bleomycin is a glycopeptide antitumor antibiotic derived from the soil bacterium Streptomyces verticillus. Since its discovery in the late 1950s, bleomycin…
Monograph of Paclitaxel
Introduction Paclitaxel is a semisynthetic, microtubule-stabilizing chemotherapeutic agent that has become a cornerstone in the treatment of several solid tumours. Its discovery…
Monograph of 5‑Fluorouracil
1. Introduction 5‑Fluorouracil (5‑FU) is a pyrimidine analog that has been a cornerstone of systemic antitumor therapy for more than six decades.…
Praziquantel Monograph – Pharmacology and Clinical Applications
Introduction Praziquantel is a synthetic pyrimidine derivative widely recognized as the cornerstone of therapy for a spectrum of helminthic infections, predominantly schistosomiasis…